Research Compendium/DSIP
Brain & NootropicsResearch OnlyNot For Human Consumption

DSIP

Delta Sleep-Inducing Peptide · DSIP nonapeptide

Naturally occurring nonapeptide with sleep-regulatory, stress-attenuating, and neuroendocrine modulating properties.

MECHANISM OF ACTION

DSIP (delta sleep-inducing peptide) is a neuropeptide originally isolated from rabbit thalamus by Schoenenberger & Monnier (1977). It promotes delta-wave sleep through opioid receptor modulation and GABA enhancement, without the addictive liability of pharmacological sleep aids. Additionally shown to modulate the HPA axis - reducing ACTH and cortisol under stress conditions - and exert antioxidant and anti-apoptotic neuroprotective effects in some rodent models. Also used in Russian clinical practice for stress and withdrawal syndromes.

RESEARCH APPLICATIONS

  • Sleep quality and delta-wave architecture research
  • HPA axis stress response modulation
  • Opioid withdrawal and substance dependence models
  • Neuroprotection and anti-apoptotic models
  • Circadian rhythm and neuroendocrine research

RESEARCH HIGHLIGHTS

Original Delta Sleep Induction

1977

First characterised as the active component in cerebral venous blood of sleeping rabbits - intraventricular injection produced reproducible delta sleep pattern in recipient rabbits.

Ref: Monnier et al., Pflügers Arch

HPA Axis Attenuation

1986

DSIP administration reduced ACTH and corticosterone response to restraint stress in rodent models, proposing a role in HPA axis buffering.

Ref: Graf & Kastin, Neurosci Biobehav Rev

RESEARCH PROTOCOL NOTES

Research doses0.5–1 mg SC in human studies
TimingPre-sleep administration in sleep research protocols
Available formatsVial (lyophilised)

Chemical Identity

Molecular FormulaC35H48N10O15
Molecular Weight848.8 g/mol
CAS Number62568-57-4
Half-Life (t½)Very short in plasma - minutes; CNS receptor residence longer
SolubilitySoluble in water

Sequence

Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

Storage & Stability

Lyophilised: -20°C. Reconstituted: 2–8°C, 14 days. Relatively unstable in solution - use promptly.

Regulatory Status

Used in Russian practice for stress/withdrawal (not formally registered as drug). No FDA/EMA approval. Research compound. Not WADA prohibited.

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